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October 1953

EFFECTS OF CORTISONE AND CORTICOTROPIN ON PROLONGED BLEEDING TIME: Treatment in Certain Hemorrhagic States (Pseudohemophilia)

Author Affiliations


From the Medical Service, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School.

AMA Arch Intern Med. 1953;92(4):471-477. doi:10.1001/archinte.1953.00240220019005

DURING General Hospital a relatively large number of patients with bleeding from various sites in whom there has been found no pertinent organic disease and whose platelets, clotting time, and prothrombin time have been essentially normal. The one defect common to all of these patients is a prolonged bleeding time. The apparent recent increase in frequency of these cases in this hospital can probably be ascribed to improvement in the method of determining the bleeding time. Among many of our patients a history of repeated bleeding episodes over a period of years was noted, but among others such a history was lacking until the present episode.

A number of these patients might be classified as persons with pseudohemophilia.1 This hitherto rare condition has been thoroughly described in the monographic paper by Estren, Sanchez Medal, and Dameshek,2 who documented some 62 cases in the previous literature and added a

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