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October 1953

STUDIES ON HEADACHE: Evidence of Tissue Damage and Changes in Pain Sensitivity in Subjects with Vascular Headaches of the Migraine Type

Author Affiliations


From The New York Hospital and the Departments of Medicine (Neurology) and Psychiatry, Cornell University Medical College.

AMA Arch Intern Med. 1953;92(4):478-484. doi:10.1001/archinte.1953.00240220026006

TO ASCERTAIN whether the cranial vascular functions of subjects with vascular headache are in any way different from those of subjects without headache, cranial artery pulse wave contour records were obtained two to five times weekly on 40 subjects with vascular headaches of the migraine type. These were taken both during headache and in headache-free phases over a period of one to six months. Such records were contrasted with records similarly taken on 10 subjects who never or but rarely had headaches.1

It became evident that even during headache-free phases the person who is subject to vascular headaches exhibits significantly greater variation in the contractile state of certain parts of the cranial vascular tree than does a person who is not subject to headache. Such variability in the headache-free phase is especially evident during those periods of life that are marred by severe and frequent attacks. About 72 hours

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