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October 1953

PERIODIC DISEASE: Observations on Old Cases and Report of New Cases and of Therapeutic Trials

Author Affiliations


From American University, Beirut, Lebanon; Dr. Reimann is Visiting Professor of Medicine.

AMA Arch Intern Med. 1953;92(4):494-506. doi:10.1001/archinte.1953.00240220042009

IN PREVIOUS publications the name periodic disease was proposed to cover an assortment of disorders of unknown cause which have in common regular short episodes of disease recurring over many years without affecting the general health.1 They were named according to their outstanding clinical feature, respectively, as periodic fever, periodic abdominalgia, periodic arthralgia, and periodic neutropenia. Certain cases of anaphylactoid (Schönlein-Henoch) purpura and of angioneurotic (Quincke's) edema were included in the scheme with the new names of periodic purpura and periodic edema, but the place of periodic paralysis, the cyclic vomiting of children, and others was uncertain. After a review of the subject was published,2 new cases of the kinds already described, some of them with unusual features, and examples of other recurrent disorders came to my attention. They were gathered by correspondence with physicians, from published reports in journals, from the Queries and Minor Notes column of

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