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October 1953


Author Affiliations


From the Infectious Disease Section of the Medical Service, the Bacteriological Section of the Laboratory Service, and the Thoracic Section of the Surgical Service, Veterans Administration Medical Teaching Group Hospital.

AMA Arch Intern Med. 1953;92(4):571-586. doi:10.1001/archinte.1953.00240220119015

SEVERAL reports of single cases of chronic pulmonary histoplasmosis were published following the first cases described by Bunnell and Furcolow1 and by Johnson and Batson2 in 1948. Each case was thought to be exceptional, and this clinical type of histoplasmosis was not described as a separate clinical type by reviewers. When four cases with manifestations consistent with the term "active chronic pulmonary histoplasmosis" were recognized by us in three years, the experience suggested that this clinical form of histoplasmosis is relatively frequent under the conditions of our practice. During this same period only three cases of generalized histoplasmosis of the clinical types most frequently reported by others were recognized. The major clinical manifestations of seven cases of chronic pulmonary histoplasmosis previously reported and the major clinical manifestations of four new cases to be reported below have been compared to provide a composite clinical description of this active but

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