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October 1953

BENIGN ASEPTIC MENINGITIS DUE TO LEPTOSPIRA GRIPPOTYPHOSA: Second Report of Clinical Infection in the United States

Author Affiliations


From the Medical Service, U. S. A. F. Hospital, Chanute A. F. B.. Illinois.

AMA Arch Intern Med. 1953;92(4):587-590. doi:10.1001/archinte.1953.00240220135016

THE SEVERAL pathogenic leptospira produce in man a group of closely related diseases. These infections have received considerable attention in Europe for many years. In the United States, leptospirosis has been identified almost exclusively with that due to Leptospira icterohaemorrhagiae (leptospiral jaundice, Weil's disease). It is becoming more obvious that other leptospiral disease is present. Several dozen cases of infection with Leptospira canicola (canicola fever),1 several instances of infection with Leptospira pomona (swineherd's disease),2 and an outbreak of disease attributed to Leptospira autumnalis (pretibial fever, Fort Bragg fever, autumnal fever)3 have been noted in this country. In November, 1952, Spain and Howard4 reported the first case of leptospirosis due to Leptospira grippotyphosa (mud fever) in the United States. Their patient had an icteric febrile illness. We are reporting a patient with an anicteric course marked by a benign aseptic meningitis. This is the second instance, to our knowledge, of leptospirosis