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October 1953

Physiological and Therapeutic Effects of Corticotropin (ACTH) and Cortisone.

AMA Arch Intern Med. 1953;92(4):602. doi:10.1001/archinte.1953.00240220150019

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"Physiological and Therapeutic Effects of Corticotropin (ACTH) and Cortisone" offers the reader a short fairly concise review of the subject outlined in the title. The book's main contribution is contained in the first half, in which the physiological aspects of the steroids are discussed with reference to the initial research studies involved. The steroids are compared as to their effect on various functions of body physiology, such as "survival and vigor," "circulation," "pain," "organic metabolism," "growth," and "electrolyte and water metabolism."

The facts gained through the numerous research studies in the field do not, however, reduce themselves into a compact and simple theory. The results of these studies at times appear to be inconsistent, even contradictory. It is not an easy book to read, nor are the facts included easily absorbed. But, besides the value of a thorough review of the basic physiology, one needs a reminder of the widespread

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