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November 1953

ACUTE RELAPSING PANNICULITISReport of a Case of Weber-Christian Disease with Vascular Changes

AMA Arch Intern Med. 1953;92(5):750-759. doi:10.1001/archinte.1953.00240230150013

WE RECENTLY investigated a 27-year-old woman with an illness of 10 years' duration, consisting of recurrent acute episodes of fever, marked toxic symptoms, and excruciating muscular pains, associated with the exhibition of crops of subcutaneous lesions primarily involving the panniculus. These episodes, lasting from one to six months, were followed by periods of complete remission. Secondary causes of panniculitis were eliminated, and a thorough search for a possible etiologic agent was unsuccessful. The clinical impression of Weber-Christian disease was confirmed by tissue examination. The purpose of this report is to call attention to the acute variant of this syndrome and to the considerable vascular changes that were present.

CASE REPORT  F. B., a 27-year-old white single female secretary, enjoyed good health until the age of 18, at which time she apparently suffered an upper respiratory infection, associated with pain in the right ear. Shortly after this acute pains developed in