EXPERIMENTAL renal hypertension in animals is associated with polyuria, albuminuria, and sometimes edema. These manifestations may be evident whether the hypertension results from manipulation of both kidneys or of one kidney. In the latter event the function of the normal kidney is apparently altered.
Since 1937, when Butler4 reported the cure of a hypertensive child by nephrectomy, it has been known that unilateral kidney disease can cause reversible hypertension in humans. The review by Smith29 in 1948 emphasized the difficulty of distinguishing these cases preoperatively. Perera and Haelig24 have recently described one type of clinical history which, when present, can help in so distinguishing them. There have been many analyses of the underlying diseases of the affected kidney, but little emphasis has been placed on the effects of this type of process other than the elevation of arterial pressure, although such effects are well known in experimental
QUENTIN B. DEMING. ASSOCIATION OF POLYURIA AND ALBUMINURIA WITH HYPERTENSION OF UNILATERAL RENAL ORIGIN. AMA Arch Intern Med. 1954;93(2):197–204. doi:10.1001/archinte.1954.00240260033003