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February 1954

CARDIOVASCULAR DISEASES: A Review of Some Significant Publications (July 1949-June 1952)

Author Affiliations

MONTCLAIR, N. J. With the Editorial Assistance of Edward F. Bland, M.D., Boston

From the Cardiac Laboratory, Massachusetts General Hospital, Boston.

AMA Arch Intern Med. 1954;93(2):254-298. doi:10.1001/archinte.1954.00240260090008

THE THREE years of cardiovascular literature encompassed by this report have witnessed a steady advance in the development of new techniques and promising agents for the recognition and the relief of cardiovascular disorders. The following review of these contributions, representative rather than inclusive, has been arranged under 10 main headings.

I. CONGENITAL HEART DISEASE  The fundamental causes of congenital heart disease continue to excite investigation and speculation. Maternal rubella, established beyond dispute as a prime cause of congenital defects, has, according to Swan,1 three chances out of four of resulting in a congenitally defective infant if contracted during the first four months of pregnancy. The critical period for the development of cardiac defects is from the fifth to the eighth week of intrauterine life, during which time the septa are forming, the bulbus cordis is undergoing involution, and the torsion of the great vessels is taking place. There is no

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