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February 1954

Gout and Gouty Arthritis.

AMA Arch Intern Med. 1954;93(2):309. doi:10.1001/archinte.1954.00240260145014

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This 80-page monograph is modeled after the original 130-page reprinted monograph which was published in Oxford Loose-Leaf Medicine. In this second monograph the history of gout is briefly discussed and the incidence, predisposing factors, and the influence of hereditary predisposition to gout are briefly presented. The intermediary metabolism of uric acid is discussed in detail, with the recent utilization of isotopic compounds. The pathologic anatomy is comprehensively reviewed. There are 24 excellent photographs of x-rays of gouty changes in the various stages of the disease. The classification, symptoms, and complications are presented in brief but are extensive enough for a practical discussion of the essential important details. The chapter on treatment includes the newer agents, corticotropin (ACTH), cortisone, probenecid (Benemid), and phenylbutazone. In discussion of the diet in gout the author questions the stigma of proteins in the pathogenesis of gout on the basis of his own work and that

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