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February 1954

Synovial Fluid Changes in Joint Disease.

AMA Arch Intern Med. 1954;93(2):310. doi:10.1001/archinte.1954.00240260146018

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This book is a monograph which presents the data which have been gathered in 20 years of study of synovial fluid in 1,500 examinations of joint fluid, chiefly from the knee joint, in patients seen at the Massachusetts General Hospital.

The authors first discuss the normal values of some of the characteristics of the joint fluid, such as pressure, amount, total and differential cell counts, and the amount of protein and mucin present in the fluid.

Using these values as a baseline, the authors then discuss and tabulate the changes in these characteristics as they occur in all the known disorders of joints. For this purpose, they divide all such diseases into two groups: Group 1, those conditions of traumatic origin, and Group 2, those of infectious origin and rheumatoid arthritis. They stress the importance of repeated aspiration of joints, for both therapeutic and prognostic reasons. They also consider the

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