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March 1954

Fibrocystic Disease Of The Pancreas.

AMA Arch Intern Med. 1954;93(3):477. doi:10.1001/archinte.1954.00240270163019

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This monograph is a collection and detailed survey of cases of fibrocystic disease of the pancreas seen at The Hospital for Sick Children, in London. An account of the literature is presented which is clear and concise. A chapter on clinical material conveys the over-all features of 116 case reports, to include the natural history of fibrocystic disease of the pancreas; various laboratory investigations, such as pancreatic enzyme determinations and roentgenologic data, and the treatment of the disease. There is an outstanding chapter on the familial incidence of the disease, in which 77 family trees are studied. The chapter on pathology is detailed and is abundant with gross photographs and photomicrographs. The main concept is that fibrocystic disease of the pancreas is the result of "mucosis," a fundamental abnormality of mucous secretion of epithelial cells wherever in the body mucus is secreted. Hence, there are found histologic lesions in the

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