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April 1954


Author Affiliations


From the Department of Medicine, University of Washington School of Medicine, and the King County Hospital.

AMA Arch Intern Med. 1954;93(4):556-560. doi:10.1001/archinte.1954.00240280076008

ERYTHROMYCIN, a derivative of Streptomyces erythreus, is effective chiefly against Gram-positive bacteria, and in this respect it resembles penicillin.1 Perhaps the most promising attribute of this antibiotic is its effectiveness against strains of staphylococci which are penicillin-resistant. Pneumococci and streptococci are also highly sensitive to erythromycin, and blood levels which are highly effective against these organisms are readily obtained following oral administration of the drug.2 Side-reactions are rare and consist for the most part of mild gastrointestinal disturbances.

The present study was undertaken to evaluate erythromycin in the treatment of adult patients with pneumonia caused by Gram-positive bacteria.

METHODS AND MATERIALS  Seventy-five adult patients admitted to the infectious disease ward of King County Hospital from July, 1952, to July, 1953, with bacterial pneumonia were treated with erythromycin. The patients were predominantly in the older age groups. Many were suffering from the multiple concomitant diseases which are so common

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