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May 1954

SICCA SYNDROME: Gougerot-Sjögren Disease

Author Affiliations


From the Department of Laboratories and Medical Service, Lebanon Hospital.

AMA Arch Intern Med. 1954;93(5):731-741. doi:10.1001/archinte.1954.00240290089010

THE SYMPTOM complex of dryness of the eyes and mucous membranes with enlargement of the parotid glands in menopausal women was described by Henri Gougerot in 19251 and has been the subject of numerous studies reported by the Swedish ophthalmologist, Henrik Sjögren (1933-1952).* Frequent references to Sjögren's disease, Gougerot's disease, and Sjögren-Gougerot or Gougerot-Sjögren disease and/or syndrome appear in European medical literature; such reports are rare in American medical journals at the time of writing and are confined chiefly to the field of ophthalmology.† There is good reason to believe that this syndrome is a manifestation of a systemic disease. Keratoconjunctivitis sicca, rhinitis sicca, pharyngitis sicca, xerostomia, and swelling of the parotid glands are cardinal features. In addition, rheumatoid arthritis, dental caries, accelerated sedimentation rate, achylia gastrica, diminished perspiration, dryness of the vulva and vagina, altered glucose-tolerance curve, hypochromic anemia, alopecia, Raynaud phenomena and scleroderma have been described.18

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