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August 1954


AMA Arch Intern Med. 1954;94(2):326-327. doi:10.1001/archinte.1954.00250020160011

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CLINICALLY, it has been established that the prolonged use of cortisone results in a temporary depression of the adrenal secretions. It is this depressive effect on adrenal function that makes it possible to control carcinoma of the prostate gland after orchectomy and the estrogens have lost their therapeutic effect. Sudden withdrawal of cortisone may result in an acute adrenal insufficiency. Hydrocortisone is a drug equivalent to cortisone in its physiological effects on the patient. We recently treated a patient for acute adrenal crisis when hydrocortisone had been substituted for cortisone. The two drugs have identical physiological effects in the dosage ratio of hydrocortisone 65 mg. to cortisone 100 mg. The literature does not clearly state whether cortisone depresses more adrenal functions than does hydrocortisone. Our experience with this patient suggests there is a difference which may produce serious consequences.

REPORT OF A CASE  A white woman, aged 33, was seen

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