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September 1954

CARBOHYDRATE METABOLISM IN BRAIN DISEASE: II. Glucose Metabolism in Schizophrenic, Manic-Depressive, and Involutional Psychoses

Author Affiliations


From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School, Boston.

AMA Arch Intern Med. 1954;94(3):402-416. doi:10.1001/archinte.1954.00250030072008

THE carbohydrate metabolism in schizophrenia and in manic-depressive and involutional psychoses have long been controversial subjects.1 The experiments described here were designed to throw light on these questions about the carbohydrate metabolism in psychotic patients.

MATERIAL AND METHODS  The subjects studied were psychotic patients and normal adult subjects of comparable age. The psychotic patients were suffering from schizophrenic, manic-depressive, or involutional psychoses; had no other intercurrent disease; were well nourished and not debilitated; were not receiving shock therapy, and were cooperative during the study; the women had normal menstrual function. All subjects had a high carbohydrate intake, in addition to their adequate normal diets, for three to five days before each experiment. They were at rest throughout the study and in the fasting state at the time the initial blood specimen was taken.The methods used were that of Folin and Wu for blood glucose,2 that of Somogyi

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