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This is the fifth edition and the first revision in 15 years of this excellent reference work. The general outline of the book has remained the same. The material previously covered has been revised and brought up to date. Seven new chapters have been added. A consideration of individual processes in urine formation is now Chapter 1. Diabetic glomerulosclerosis is adequately handled in a chapter of its own. The author points out the development of the importance of chronic pyelonephritis and covers it in a new paragraph but devotes only 10 pages to it in spite of stating in the second sentence of the opening paragraph, "Indeed, if both the acute and chronic stages of pyelonephritis are included, it is doubtless much the most frequent of kidney diseases." The etiology and pathogenesis of pyelonephritis is inadequately covered in one short paragraph. The importance of pyelonephritis in the production of hypertension