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Article
December 1954

CONTINUOUS THERAPY OF NEPHROTIC SYNDROME IN CHILDREN WITH CORTICOTROPIN GEL

AMA Arch Intern Med. 1954;94(6):925-930. doi:10.1001/archinte.1954.00250060059005
Abstract

INTERMITTENT treatment with adrenocorticotropic hormone, first described by Farnsworth,1 is a definite milestone in the management of the nephrotic syndrome. Diuresis is accomplished in 45 to 80% of the cases,* and in many improvement is maintained. Those who require repeated courses, however, swing from an edematous state to a dehydrated, washed-out, debilitated condition and are rarely well enough to live normal lives. They eat voraciously at times and are anorectic at others.

In the summer of 1951, when a 3-year-old child failed to have her usual diuretic response following a 12-day course of corticotropin (ACTH) treatment was resumed at a lower dosage level for two more weeks, after which complete diuresis occurred. The child (L. H.) had had a series of 10 courses by March 3, 1952. Between courses albuminuria would disappear, only to reappear in a few days followed by edema. She was never well enough to permit

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