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Article
January 1955

TREATMENT OF LOCALIZED HISTOPLASMOSIS WITH 2-HYDROXYSTILBAMIDINE

Author Affiliations

Hines, III

From the Veterans Administration Hospital.

AMA Arch Intern Med. 1955;95(1):37-40. doi:10.1001/archinte.1955.00250070053006
Abstract

THE TREATMENT of histoplasmosis, particularly of the progressive disseminated type, has been for the most part unsuccessful. In vitro studies by Seabury and Artis 1 revealed that stilbamidine is an effective histoplasmocidal agent, and Snapper has shown that 2-hydroxystilbamidine inhibits the growth of histoplasma capsulatum in vitro in concentrations of 20 to 40 γ per milliliter.2 Because of these findings and inferred benefit from stilbamidine in disseminated cases, we felt that a clinical trial with 2-hydroxystilbamidine was indicated in a case of localized histoplasmosis of the hard palate recently admitted to the Veterans Administration Hospital, Hines, Ill.

REPORT OF A CASE  A 53-year-old white man, a cattle farmer from Nebraska, first noted a painful area involving the gingiva in the region of his left upper premolar teeth in May, 1953. A small nodule developed in this area, and approximately one month after onset of symptoms it became ulcerated. At

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