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Each of the seven papers in this symposium is a well-rounded view of important aspects of protein metabolism which are now under investigation. Among the more important subjects discussed are the relations of vitamin B6, riboflavin, and vitamin B12 to protein metabolism; the role of vitamins in antibody production as a measure of protein synthesis; the effects of growth hormone on protein metabolism; the amino acid requirements of man, and the use of amino acids and proteins in therapy.