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January 1955

Serological Approaches to Studies of Protein Structure and Metabolism.

AMA Arch Intern Med. 1955;95(1):179. doi:10.1001/archinte.1955.00250070195034

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This monograph is a report of the proceedings of the Tenth Annual Conference on Protein Metabolism, sponsored by the Bureau of Biological Research, at Rutgers University. It is highly technical, concerning primarily the fundamental study of the nature of the precipitin reaction and how this reaction reveals the basic structure of proteins, as well as how the steps in their synthesis and degradation occur.

The first of the six topics considered, proteins as antigens and antibodies, is discussed by Felix Haurowitz. The use of trace-labeled proteins in demonstrating a two-phase process in the formation of antibody protein is reported.

This is followed by a report on the precipitin reaction and studies of native and denatured proteins and derivatives, by Michael Heidelberger. The precise knowledge that accrued with the advent of quantitative antibody estimation is reviewed.

The third report, by David Gitlin, deals with light scattering and ultracentrifugation methods in studies

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