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February 1955

STUDIES IN IRON TRANSPORTATION AND METABOLISM: VIII. Absorption of Radioiron from Iron-Enriched Bread

Author Affiliations

St. Louis

From the Department of Internal Medicine, Washington University School of Medicine.

AMA Arch Intern Med. 1955;95(2):181-193. doi:10.1001/archinte.1955.00250080003001

THE INVESTIGATIONS reported INVESTIGATIONS low were designed to study the nutritional value of fortifying flour with iron. The four different iron preparations most commonly used in the enrichment program (ferrous sulfate, reduced iron, ferric orthophosphate, and sodium ferric pyrophosphate) were made from radioactive iron (Fe59) of high specific activity and were baked into bread under conditions which closely simulated those employed in the baking industry. Absorption of Fe59 from the enriched bread was then measured in human subjects. This kind of evaluation has been long overdue. The original recommendation of the Council on Foods and Nutrition of the American Medical Association 1 emphasized that there obviously would be no nutritional advantage in enriching bread or other food with iron if the added iron were not available for absorption. Yet the iron preparations which have come to be used, with the exception of ferrous sulfate, are certainly not the ones that

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