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February 1955

CARBOHYDRATE METABOLISM IN BRAIN DISEASE: IV. Effect of Hydrocortisone and Corticotropin (ACTH) on the Metabolic Effects of Administered Glucose in Patients with Chronic Schizophrenic and Manic-Depressive Psychoses

Author Affiliations

Boston; Waverley, Mass.

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, and the Department of Medicine, Harvard Medical School, Boston; postdoctorate Fellow, U. S. Public Health Service, National Institute of Mental Health (Dr. Henneman).

AMA Arch Intern Med. 1955;95(2):241-246. doi:10.1001/archinte.1955.00250080063008

ABNORMAL changes in the concentrations of blood glucose and its breakdown products occur following the administration of glucose in patients with schizophrenic, manic-depressive, and involutional psychoses.1 After the administration of glucose by mouth there is often a lag in the return to the fasting level of the blood glucose concentration and there is no fall below the fasting level at two or three hours. The patients often also show an excessive rise in the blood lactic and pyruvic acid concentration and a rise instead of the normal fall in the blood citric and a-ketoglutaric acid concentrations. In addition, many patients show an excessive and prolonged fall in serum inorganic phosphate level. All the patients studied here have shown at least three of these abnormalities, and some manifested all of them. The duration of mental illness appears to influence the incidence and degree of abnormality seen. Patients with psychoses of