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May 1955

Epidemic of infectious Hepatitis: Some Notes on Delineation of High-Risk Groups and Protection of Exposed Susceptibles by Gamma Globulin

Author Affiliations

New York; Philadelphia; Dalton, Ga.; Atlanta

From The Children's Hospital of Philadelphia and The Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia; The Communicable Disease Center, Public Health Service, Department of Health, Education, and Welfare, Atlanta; The Dalton-Whitfield County Health Department, Dalton, Ga., and Division of Epidemiology, Georgia State Department of Public Health, Atlanta.

AMA Arch Intern Med. 1955;95(5):633-645. doi:10.1001/archinte.1955.00250110003001

Studies on the viral hepatitides of man have aroused increasing interest in the past few years, and several studies of epidemics of infectious hepatitis have been recorded.* The present report is concerned with a brief review of the literature pertinent to this problem and with recording an epidemiological study, with particular reference to delineation of high-risk groups in an open community outbreak. In addition, some observations on the effect of normal human serum gamma globulin in protecting exposed susceptibles under field conditions will be presented, and the proper application of this material in open community outbreaks will be considered.

REVIEW OF THE LITERATURE  Infectious hepatitis is a very old and common disease and has no doubt been responsible for many of the cases which physicians have been identifying as "catarrhal jaundice" for many years. Cockayne 42 cites Cleghorn's report of what was probably an outbreak of infectious hepatitis on the