Studies on the viral hepatitides of man have aroused increasing interest in the past few years, and several studies of epidemics of infectious hepatitis have been recorded.* The present report is concerned with a brief review of the literature pertinent to this problem and with recording an epidemiological study, with particular reference to delineation of high-risk groups in an open community outbreak. In addition, some observations on the effect of normal human serum gamma globulin in protecting exposed susceptibles under field conditions will be presented, and the proper application of this material in open community outbreaks will be considered.
REVIEW OF THE LITERATURE
Infectious hepatitis is a very old and common disease and has no doubt been responsible for many of the cases which physicians have been identifying as "catarrhal jaundice" for many years. Cockayne 42 cites Cleghorn's report of what was probably an outbreak of infectious hepatitis on the
BARONDESS JA, DRAKE ME, BASHE WJ, et al. Epidemic of infectious Hepatitis: Some Notes on Delineation of High-Risk Groups and Protection of Exposed Susceptibles by Gamma Globulin. AMA Arch Intern Med. 1955;95(5):633–645. doi:10.1001/archinte.1955.00250110003001
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