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May 1955

Nitrofurantoin: Clinical and Laboratory Evaluation

Author Affiliations


From the infectious disease control unit of the department of medicine of the Milwaukee County General Hospital and Marquette University School of Medicine.

AMA Arch Intern Med. 1955;95(5):653-661. doi:10.1001/archinte.1955.00250110023003

The purpose of this report is to present laboratory and clinical studies with nitrofurantoin. This drug is a derivative of the nitrofurans and has the chemical formula N- (5-nitro-2-furfurylidene) -1-aminohydantoin. It was synthesized and shown to have antimicrobial activity by the Eaton Laboratories in 1952. Norfleet and others have shown that nitrofurantoin is particularly effective in urinary tract infections due to Proteus, that it is well tolerated, and that it does not have a marked effect on the bacterial flora of the bowel.* Because infections with Proteus, toleration of antimicrobial drugs, and the development of infections due to the derangement of bowel flora by antibiotics are three of the most pressing problems in large general hospitals, we felt that further investigation of nitrofurantoin was warranted.† Forty per cent of nitrofurantoin appears in the urine within six hours after it is administered by mouth; therefore, this study, as have been previous

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