Diabetes insipidus has been found in association with xanthomatosis; sarcoidosis; pulmonary fibrosis; trauma; tumors; hemorrhage and infarcts; infections, including syphilis, tuberculosis, measles, mumps, scarlet fever, chicken pox, influenza, encephalitis, and actinomycosis; pellagra; hereditary and congenital lesions such as Laurence-Moon-Biedl-syndrome, pituitary dwarfism, and idiopathic diabetes insipidus.1
Many of the above conditions may cause or be found in association with pulmonary disease. The purpose of this paper is to discuss some of the relationships between the causes of diabetes insipidus and pulmonary disease and to present two cases of diabetes insipidus with pulmonary fibrosis and no known etiology.
Case 1.
—A 26-year-old white man was admitted to the National Naval Medical Center, Bethesda, Md., with an eight-month history of polydipsia and polyuria. He consumed up to 2 gallons (7.6 liters) of water daily and voided equally large quantities of urine. He voided approximately every 40 minutes and had nocturia as often