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June 1955

Survey of Antimalarial Agents: Chemotherapy of Plasmodium Gallinaceum Infections; Toxicity; Correlation of Structure and Action; Public Health Monograph No. 9.

AMA Arch Intern Med. 1955;95(6):875. doi:10.1001/archinte.1955.00250120111021

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This monograph is a summary of the screening data obtained in seven-day-old chicks on the toxicity and therapeutic and prophylactic effectiveness of nearly 4,000 chemical substances synthesized in 128 laboratories which collaborated during the war years in an attempt to produce effective substitutes for quinine. The data are classified according to chemical structure. In the concluding chapter the active compounds are compared with respect to therapeutic and prophylactic antimalarial action. The volume is a logical compilation of limited data and would be of great value only to investigators in the field of antimalarial chemotherapy.

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