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August 1955

DIABETES INSIPIDUS: Clinical and Experimental Studies with Consideration of Genetic Relationships

Author Affiliations

Salt Lake City

AMA Arch Intern Med. 1955;96(2):215-272. doi:10.1001/archinte.1955.00250130089012

DIABETES insipidus was first differentiated from diabetes mellitus by Thomas Willis, in 1674. The term diabetes is derived from the Greek word for syphon, and insipidus differentiates this disease from mellitus, which connotes a honey taste. Diabetes insipidus has been defined as a chronic affection marked by extreme thirst, polyuria, nocturia, and an absence of glycosuria. In this study those affected with hereditary diabetes insipidus are referred to among their families by terms such as "water topers," "drinkers," "drinking babies." It is a relatively rare condition seen in all ages and both sexes; however, it is noted more frequently in males than in females. The basis for this finding is demonstrated in the following study.

CLASSIFICATION  Clinically and etiologically diabetes insipidus is divided according to the following classification, the basis for which is presented in this study:

  1. Pituitary type: There is pituitary deficiency, in which the symptoms are relieved by

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