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October 1955

Experiences with 2-Hydroxystilbamidine in Systemic Sporotrichosis: Report of An Unusual Case

Author Affiliations

Rochester, Minn.

From Mayo Clinic and Mayo Foundation; Section of Medicine (Drs. Geraci and Dry), Section of Bacteriology (Drs. Ulrich and Weed), Section of Neurologic Surgery (Dr. MacCarty), and Section of Pathologic Anatomy (Dr. Sayre). The Mayo Foundation is a part of the Graduate School of the University of Minnesota.

AMA Arch Intern Med. 1955;96(4):478-489. doi:10.1001/archinte.1955.00250150052005

Systemic sporotrichosis involving the skin, bones, viscera, and central nervous system is rare.* Recent reviews of sporotrichosis make only passing mention of this unusual syndrome. Collins 3 has reported the case of a 67-year-old man with disseminated cutaneous and visceral lesions. Clinically, except for the cutaneous involvement, the patient was asymptomatic. Enlargement of the liver and spleen was noted on physical examination. At necropsy, however, multiple visceral lesions were observed in the form of microscopic miliary granulomas. The skin, lungs, spleen, liver, kidneys, adrenals, cerebral cortex, and bone marrow were involved. Cawley 1 has reported the case of a 70-year-old man who had multiple disseminated subcutaneous gummatous lesions and probable osseous lesions and who apparently was cured with iodides. Moore and Kile 14 reported a case of generalized subcutaneous gummatous ulcerating sporotrichosis with skin and pulmonary lesions which apparently cleared up with iodide therapy.

Involvement of the central nervous system

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