Chloramphenicol (Chloromycetin) at present is the best therapeutic agent available for typhoid. Because it is not the ideal one, some early observers felt that the drug was useful chiefly in the first few days of fever. Given later it presumably controlled the symptoms without significantly influencing the pattern of recovery. Salmonella typhosa may persist in the blood and feces, and relapse may occur during treatment.* It was thought also that early treatment retarded the immune response to infection. The incidence of relapse was unchanged in treated patients and in some instances was actually higher.3 Nine per cent of Watson's 110 patients responded poorly or not at all to therapy, and toxicity from the drug occurred in 10% in the form of nausea, vomiting, urticaria, and oral moniliasis. Large initial doses seemed to be harmful in severe cases.
Despite the reported shortcomings of antibiotic therapy just mentioned, statistics compiled from
REIMANN HA, LIAN PT. Chloramphenicol in Paratyphoid A: Observations with a Note on the Clinical Aspects of the Disease. AMA Arch Intern Med. 1955;96(6):777–780. doi:10.1001/archinte.1955.00250170083012
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