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January 1956

Carbohydrate Metabolism: I. A Study of Changes in Serum Inorganic Phosphorus During Glucose-Tolerance Test in Normals, Diabetics, and Prediabetic Women

Author Affiliations

Los Angeles

From the Departments of Medicine and Pharmacology, University of Southern California School of Medicine, and the Diabetic Clinic, Los Angeles County General Hospital.

AMA Arch Intern Med. 1956;97(1):62-67. doi:10.1001/archinte.1956.00250190078006

For some time it has been known that phosphate ion is involved in the intermediary metabolism of glucose.* The phosphorylation of glucose in transport to the liver and the subsequent changes in the metabolism of carbohydrate (as in the Embden-Meyerhof scheme), to mention only two, involve the participation of phosphorus radicals as necessary groupings. The subject is intriguing and has stimulated numerous investigators to perform both in vivo and in vitro experiments on the changes of phosphorus in metabolic processes. In the recent past, observations have been published linking changes in the serum inorganic phosphorus to the presence or absence of diabetes mellitus.3 Thus, during the course of an intravenous glucosetolerance test considerable drop in serum phosphate level was noted in the normal but a lesser fall in the diabetic. These values are considered important by those authors who emphasize that this change in phosphorus may be directly affected

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