For some time it has been known that phosphate ion is involved in the intermediary metabolism of glucose.* The phosphorylation of glucose in transport to the liver and the subsequent changes in the metabolism of carbohydrate (as in the Embden-Meyerhof scheme), to mention only two, involve the participation of phosphorus radicals as necessary groupings. The subject is intriguing and has stimulated numerous investigators to perform both in vivo and in vitro experiments on the changes of phosphorus in metabolic processes. In the recent past, observations have been published linking changes in the serum inorganic phosphorus to the presence or absence of diabetes mellitus.3 Thus, during the course of an intravenous glucosetolerance test considerable drop in serum phosphate level was noted in the normal but a lesser fall in the diabetic. These values are considered important by those authors who emphasize that this change in phosphorus may be directly affected
KRITZER MD, SHRIFTER N, DEMETRIOU JA. Carbohydrate Metabolism: I. A Study of Changes in Serum Inorganic Phosphorus During Glucose-Tolerance Test in Normals, Diabetics, and Prediabetic Women. AMA Arch Intern Med. 1956;97(1):62–67. doi:10.1001/archinte.1956.00250190078006
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