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February 1956

A Comparative Study of the Treatment of Essential HypertensionThe Effect of Rauwolfia and a Rauwolfia Compound (Rauwolfia, Mannitol Hexanitrate, and Rutin)

AMA Arch Intern Med. 1956;97(2):189-193. doi:10.1001/archinte.1956.00250200065005

Although Rauwolfia has been used in India for centuries because of its sedative effect in such conditions as insanity, hysteria, insomnia, etc., it was not until 1933 that its hypotensive effect was reported.1 In 1931 Siddiqui and Siddiqui2 were able to isolate five crystalline alkaloids from the whole alkaloid Reserpine. These compounds have been used in combination with other hypotensive drugs such as hexamethonium, pentolinium (pentapyrrolidinium), hydralazine, and Veratrum alkaloids.* This study concerns itself with the hypotensive effect of the powdered whole root from Rauwolfia micrantha alone and when combined with rutin and mannitol hexanitrate (Maxitate).

MATERIALS AND METHODS  A total of 17 patients with moderate to severe hypertension were observed for a period of one year. The blind test technique was used. All tablets were of identical appearance, and were labeled 7-71, 7-72, and 7-73. The composition of the tablets is as follows:7-71 Rauwolfia micrantha.... 30

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