Primary atypical nonbacterial pneumonia has emerged from relative obscurity to particular prominence during the past 20 years.* Despite the increased frequency with which this disease is now recognized, there have been few large published series with adequate controls and serial clinical and laboratory studies which evaluate the efficacy of the various therapeutic agents presently available. The opportunity to evaluate critically the therapeutic effect of various antibiotics in a large population of patients with primary atypical nonbacterial pneumonia is infrequently available.4 These populations, however, occasionally occur when large numbers of people congregate in military installations. Unbiased sampling of a large population of patients with primary atypical nonbacterial pneumonia may be undertaken, under these conditions.In the year 1812, cases of pneumonitis identical in both clinical and pathological description to primary atypical nonbacterial pneumonia were first described.5 Little attention was given to the disease until 1934, when disparity between
WOLF RL, BROWN LT. Primary Atypical nonbacterial Pneumonia: An Evaluation of the Efficacy of Antibiotic Therapy in One Hundred Eighteen Cases. AMA Arch Intern Med. 1956;97(5):593–598. doi:10.1001/archinte.1956.00250230087009
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