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June 1956

Sitosterol Administration in Normal and Hypercholesteremic Subjects: The Effect in Man of Sitosterol Therapy on Serum Lipids and Lipoproteins

AMA Arch Intern Med. 1956;97(6):738-752. doi:10.1001/archinte.1956.00250240090008

The postulated relationship between dietary intake of fats, serum cholesterol level, and the pathogenesis of atherosclerosis has been the basis for the prophylactic use of diets low in fat and cholesterol. The recent demonstration that orally administered plant sterols, without reduction of cholesterol and fat intake, can lower the serum cholesterol levels of animals 1 and man* has provided a new approach to this therapeutic problem. However, failures of treatment with plant sterols to affect serum cholesterol levels of human subjects also have been reported.† Because of these discrepant observations, the preliminary results of the present study were withheld until the effects of the more prolonged administration of a mixture of β- and dihydro-β-sitosterols on the serum cholesterol and lipoproteins of normal subjects and hypercholesteremic patients with disorders of lipid metabolism could be evaluated.


Experiment A.  —Five normal persons without demonstrable clinical disease and one patient with

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