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June 1956

CHRONIC LYMPHOCYTIC LEUKEMIA: Report of a Case with Marked Uric Acid Crystalluria

Author Affiliations

Springfield, Mo.; San Francisco

From the Medical Service, United States Public Health Service Hospital, San Francisco.

AMA Arch Intern Med. 1956;97(6):817-819. doi:10.1001/archinte.1956.00250240169020

INTRODUCTION  HYPERURICEMIA, with and without renal involvement, has become recognized as a complication of leukemia and other allied disorders.1 This may be seen in the untreated patient, but it is more commonly observed following therapy by those agents causing rapid cell destruction.* We wish to report such a case that was followed closely for eight months.

REPORT OF CASE  A 45-year-old white man, American seaman, was admitted to the U. S. Public Health Service Hospital, San Francisco, on Jan. 6, 1954, because of swelling in the neck. He had been perfectly well until 10 days prior to admission, when he noticed nodular enlargements in his neck. These were neither painful nor tender, but they continued to increase in size gradually. He was otherwise asymptomatic, and past history was noncontributory.Physical examination revealed a short slightly obese white man with moderate pallor. Temperature was 100 F; pulse rate, 92; respiration rate,