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July 1956

Clinical Diseases of Adults Associated with Sporadic Infections by APC Viruses

Author Affiliations

San Francisco

From the Departments of Microbiology, Medicine, and Ophthalmology, University of California School of Medicine.

AMA Arch Intern Med. 1956;98(1):71-79. doi:10.1001/archinte.1956.00250250077010

The adenoidal-pharyngeal-conjunctival (APC) viruses are a large group of infectious agents comprising at present at least nine human and two simian types.1 The first of these agents was discovered by Rowe,2 who isolated it in cultures of adenoidal and tonsillar tissue removed at surgery. Types 1, 2, 5, and 6 appear to be common latent agents in such lymphoid tissue, but they have only rarely been implicated in spontaneous disease.* Type 3 APC virus was established as the etiologic agent in epidemic outbreaks of "pharyngoconjunctival fever," particularly in children, by Bell.4 Type 4 appears to be identical with the RI 67 virus originally isolated and described by Hilleman and Werner 5 from cases of undifferentiated acute respiratory disease (ARD) or primary atypical pneumonia (PAP) in military recruits. Serological evidence implicated this agent as the important cause of epidemic respiratory illnesses, including ARD, in unseasoned troops in 1945

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