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July 1956

Factors Associated with Changing Sex Ratio of myocardial Infarction: Study with Special Reference to the Disproportionate Rise in Incidence of the Disease Among Older Women

Author Affiliations

St. Louis

From the Department of Pathology, Washington University School of Medicine.

AMA Arch Intern Med. 1956;98(1):80-83. doi:10.1001/archinte.1956.00250250086011

In a recent epdemiological study of autopsied patients with acute myocardial infarction, at Washington University, it was discovered that a shift has occurred in recent years in the relative incidence of the disease in the two sexes.1 In the period 1910-1939 the incidence of acute myocardial infarction was twice as great in men as it was in women. In the period 1940-1954 the incidence was not significantly greater in men than in women. The results in a portion of the latter period have been confirmed by Acher, Burchell, and Edwards,* who found a similar ratio (1:1) between the sexes among the patients with acute myocardial infarction autopsied at Mayo Clinic during the period 1946-1950. Such a shift is of profound significance and warrants a careful search for factors that may be responsible. The purpose of this report is to present the results of a study of various factors associated

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