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August 1956

The Association of Smoking with Cancer of the Urinary Bladder in Humans

Author Affiliations

Buffalo; Albany, N. Y.; Buffalo

From the Department of Statistics and Epidemiological Research, Roswell Park Memorial Institute, Buffalo (Dr. Lilienfeld), and Division of Medical Services, Albany, N. Y. (Dr. Levin), New York State Department of Health; Director, Roswell Park Memorial Institute (Dr. Moore).

AMA Arch Intern Med. 1956;98(2):129-135. doi:10.1001/archinte.1956.00250260001001

Recently, in an experiment designed to study the effects of the intraoral application of tobacco tar as a carcinogenic agent in mice, Holsti and Ermala observed that about 75% of the mice developed urinary bladder papillomas in contrast to none of the control group and that 10% of the experimental group had papillomas that were histologically malignant.1 It would be of considerable interest to determine if in humans a similar relationship exists. As a first approach to the study of such a relationship, the clinical records of patients admitted to the Roswell Park Memorial Institute were reviewed. This is a report of the results of this analysis.

Method of Study  The method of study consisted of a comparison of the histories of tobacco use of a group of patients with urinary bladder cancer with those of patients with other cancers and noncancerous conditions. The other cancers selected for study

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