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September 1956

Adrenal Cortical Activity in Gastric Carcinoma: I. Studies of Plasma 17-Hydroxycorticosteroid Levels

Author Affiliations


From the Medical Clinic, Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School.

AMA Arch Intern Med. 1956;98(3):266-272. doi:10.1001/archinte.1956.00250270010002

Adrenal cortical function in gastric cancer has been the subject of previous investigations. Dobriner and co-workers,1 noting the presence of the abnormal steroid metabolite 11-oxyetiocholanolone on paper chromatography of urinary extracts in gastric cancer patients, postulated a disordered function of the adrenal cortex. This abnormal steroid metabolite was also present in patients with Cushing's disease.2

Young and co-workers,3 studying glucose metabolism in patients with gastric carcinoma, observed that supplementary adrenal cortical extract was necessary to produce normal hepatic glycogen deposition in patients who were receiving oral glucose feedings.

Homburger and co-workers4 have reported a disturbed water and electrolyte balance in gastric cancer patients, simulating in some respects that seen in adrenal hypofunction.

Rhoads5 applied the Kepler and the Cutler-Power-Wilder tests to two patients with gastric cancer in order to investigate the connection, if any, between neoplasm of the stomach and adrenal hormonal imbalance. The results

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