The pathogenesis of symmetrical digital clubbing has been widely discussed, but no definitive conclusions have ever been reached. Among the chief difficulties present in attempted solutions of this problem has been the extremely large variety of apparently unrelated clinical conditions in which clubbing has been found.1 Of special interest, therefore, as offering possible clues to basic pathogenesis are the occasionally reported cases of unilateral, asymmetrical, or unidigital clubbing.
Reported cases of unilateral clubbing prior to 1943 have been summarized by Sartor.2 This and other reports * yield the following information: There were 33 recorded cases of unilateral clubbing in which an aneurysm was present in relationship to the major vessels of the involved extremity. In two cases of this group, there was in each an aneurysm proximal to a coarctation of the aorta. There were three cases associated with arteriovenous aneurysm and two with nonaneurysmal dilatation of an artery.
RIBOT S. Unilateral Clubbing Following Traumatic Obstruction of the Axillary Vein: Report of a Case. AMA Arch Intern Med. 1956;98(4):482–488. doi:10.1001/archinte.1956.00250280084011
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