Understanding of the natural history of the anemias associated with increased destruction of red cells has been advanced in the past 20 years, as indicated in recent reviews.* In this report the characteristics of the red cell and the sites and mechanisms of hemolysis are considered for normal red cells and for certain hereditary, congenital, and acquired hemolytic conditions. An attempt is made to indicate the significance and limitations of knowledge concerning the hemolytic processes. More complete details concerning the pathologic physiology and, especially, the clinical aspects of hemolytic conditions are found elsewhere.f The normal red cell is a biconcave disc containing from 32 to 34 gm. of hemoglobin per 100 ml. of packed red cells. The mechanism which holds the red cell in its unique
I. Normal Red Blood Cells and Effect of Incubation
Characteristics of the Normal Red Cell Compared to Certain Abnormal Forms
shape has not been
HAM TH, WEISMAN R, HINZ CF. mechanisms of Destruction of Red Cells in Certain Hemolytic Conditions. AMA Arch Intern Med. 1956;98(5):574–592. doi:10.1001/archinte.1956.00250290034006
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