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November 1956

Collagen Diseases.

AMA Arch Intern Med. 1956;98(5):676. doi:10.1001/archinte.1956.00250290136023

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There is much doubt as to whether Klemperer's invention of the term collagen diseases has served a useful purpose or has been an impediment in our understanding of disseminated lupus erythematosus, polyarteritis, dermatomyositis, scleroderma, and thrombotic thrombocytopenic purpura, which Talbott and Ferrandis have included in their monograph entitled "Collagen Diseases." As with many catch phrases or slogans, the words have taken on new meaning. The crux of the matter is very simple. Are the proliferations of collagen, the formation of fibrinoid necrosis, and other changes which characterize the various so-called collagen diseases a result of a multitude of stimuli affecting various tissues but leading to similar results because the reactivity of tissues is limited, or is a single kind of stimulus operating in each of the various disorders whose clinical manifestations and natural history differ from case to case because of the inherent variability of living organisms? There is no

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