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December 1956

The Diagnosis of Boeck's Sarcoid by Skeletal Muscle Biopsy: Report of Four Cases

Author Affiliations

Warwick, R. I.; Weirton, W. Va.

From the Veterans Administration Hospital, Providence, R. I.

AMA Arch Intern Med. 1956;98(6):732-736. doi:10.1001/archinte.1956.00250300050007

Skeletal muscle biopsy has been found useful in obtaining pathological tissue representative of the underlying disease process in a number of conditions. These include trichiniasis and polyarteritis nodosa,2 in which specimens of diagnostic value may be found. In addition, in dermatomyositis3 and certain types of muscular dystrophy helpful histological evidence may be found by such a biopsy.4 In 1952, Myers5 and his co-workers, reporting on the joint and skeletal manifestations of sarcoidosis, noted granulomata in the skeletal muscle of three of their cases. They suggested that random gastrocnemius muscle biopsy be further evaluated as a diagnostic procedure in Boeck's sarcoid. Since then one report has appeared in the foreign literature dealing with muscle biopsy in the diagnosis of sarcoidosis.6 In view of the importance of obtaining a specimen of tissue containing the characteristic granuloma as a diagnostic aid in the patient suspected of this disease, further study of the possibilities