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Article
January 1957

The Circulating Red Blood Cell Volume: I. Its Relationship to the Peripheral Blood Cell Counts in Normal Subjects and Persons with Polycythemia

AMA Arch Intern Med. 1957;99(1):8-13. doi:10.1001/archinte.1957.00260010010002
Abstract

Introduction  The measurement of the concentration of hemoglobin or erythrocytes in the peripheral blood is probably one of the most widely employed laboratory aids in clinical medicine. Interpretation of these measurements is based upon widely used standards for normal values which were obtained by statistical studies of large groups of persons in many geographical areas.1 The impression of the existence of anemia or polycythemia is given when values obtained are respectively lower or higher than those accepted standards.An investigation of the relationship between the peripheral blood cell counts and the total body red cell volume was undertaken in a variety of clinical states. The present study deals with this correlation in a group of normal subjects and in patients with elevated erythrocyte values.

Methods  The subjects studied were patients on the wards or attending the hematology clinic at Kings County Hospital. They were selected on the basis of

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