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January 1957

Carbohydrate Metabolism in Brain Disease: VII. The Effect of Glutathione on Carbohydrate Intermediary Metabolism in Schizophrenic and Manic-Depressive Psychoses

Author Affiliations

Waverley, Mass.; Boston; Waverley, Mass.

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School, Boston.

AMA Arch Intern Med. 1957;99(1):22-27. doi:10.1001/archinte.1957.00260010024004

Patients with schizophrenic, manic-depressive, and involutional psychoses have a disorder of carbohydrate metabolism; the origin of this disorder is as yet unknown.1 However, it is known that it is not due to hepatic dysfunction,2 that it is not remedied by thiamine, and that it disappears only with remission of the psychoses, regardless of how remission has come about. It also is known that patients with these psychoses commonly have blood glutathione levels that are in or below the lower range of normal.3 Glutathione is an important coenzyme in several metabolic processes, and it also may have other functions in intermediary metabolism; at any rate, observations in man4 indicate that it accelerates carbohydrate utilization. In view of these facts, it was decided to study the effects of the administration of glutathione on the carbohydrate metabolism of patients with the above-mentioned psychoses.

Material and Methods  Five patients were

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