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January 1957

A Clinical Evaluation of the C-Reactive Protein Test

Author Affiliations

Washington, D. C.; San Francisco

From the U. S. Public Health Service Hospital, San Francisco; Senior Resident (Dr. Yocum) and Chief (Dr. Doerner), Medical Service. Present address of Dr. Yocum: U.S. Public Health Service Outpatient Clinic, 4th & D Sts., S.W. (25).

AMA Arch Intern Med. 1957;99(1):74-81. doi:10.1001/archinte.1957.00260010076011

Introduction  In response to a variety of inflammatory lesions, there appears in the blood of humans a protein substance not normally present, which is identified by its capacity to form a precipitate with the somatic Cpolysaccharide of the pneumococcus.1 It has consequently been named C-reactive protein (CRP). Present knowledge points toward C-reactive protein being a β-globulin, probably bound to a lipid. Minute amounts of this protein may be demonstrated in human serum by a precipitin test employing a specific antiserum obtained from rabbits hyperimmunized by repeated injections of a purified C-reaction protein. In previous studies it has been demonstrated that the appearance of C-reactive protein in the blood is a nonspecific but extremely sensitive indicator of an inflammatory reaction due to infection. It has also been found in other disease processes of a noninfectious nature, such as malignancy and myocardial infarction. Kroop and Shackman 2 reported negative tests in

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