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February 1957

The Thyroid-Stimulating Hormone (TSH) Test: An Aid to the Differential Diagnosis of Nontoxic Disease of the Thyroid

Author Affiliations


From the Department of Endocrinology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute. Former Fellow in Division of Medicine, Cleveland Clinic (Dr. Evans).

AMA Arch Intern Med. 1957;99(2):234-244. doi:10.1001/archinte.1957.00260020070011

The thyroidal radioactive iodine (I131) uptake alone has only been of limited value as a diagnostic aid in the differential diagnosis of nontoxic thyroid disease. However, measurement of the thyroidal uptake of radioactive iodine (I131)* before and after the administration of thyroid-stimulating hormone (thyrotropin) has greatly enhanced the usefulness of this diagnostic tool. The purpose of this paper is to describe the results of the thyroid-stimulating hormone (TSH) test in patients having various nontoxic thyroid diseases with and without goiter and patients with normal thyroid function.

Review of the Literature  Stanley and Astwood 1 first demonstrated that in patients with normal thyroid function (euthyroidism) a single injection of TSH caused a significant increase in the rate of thyroidal uptake of I131 at the end of 8 hours which reached its peak at the end of 24 hours. They noted that the duration of the increased rate of

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