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February 1957

The Thyroid-Stimulating Hormone (TSH) TestAn Aid to the Differential Diagnosis of Nontoxic Disease of the Thyroid

AMA Arch Intern Med. 1957;99(2):234-244. doi:10.1001/archinte.1957.00260020070011

The thyroidal radioactive iodine (I131) uptake alone has only been of limited value as a diagnostic aid in the differential diagnosis of nontoxic thyroid disease. However, measurement of the thyroidal uptake of radioactive iodine (I131)* before and after the administration of thyroid-stimulating hormone (thyrotropin) has greatly enhanced the usefulness of this diagnostic tool. The purpose of this paper is to describe the results of the thyroid-stimulating hormone (TSH) test in patients having various nontoxic thyroid diseases with and without goiter and patients with normal thyroid function.

Review of the Literature  Stanley and Astwood 1 first demonstrated that in patients with normal thyroid function (euthyroidism) a single injection of TSH caused a significant increase in the rate of thyroidal uptake of I131 at the end of 8 hours which reached its peak at the end of 24 hours. They noted that the duration of the increased rate of

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