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February 1957

Serum Glutamic Oxalacetic Transaminase Activity in Experimental and Disease States: A Review

Author Affiliations

New York

From the Department of Medicine of Memorial Center for Cancer and Allied Diseases and Cornell University Medical College.

AMA Arch Intern Med. 1957;99(2):245-252. doi:10.1001/archinte.1957.00260020081012

Introduction  The measurement of serum enzymes has been a useful laboratory adjunct in the clinical resolution of diagnostic problems. The recent reports that have rapidly accumulated on the clinical application of alterations in serum glutamic oxalacetic transaminase (SGO-T) justify a review of the literature pertaining to this serum enzyme and to its clinical significance.Transamination is a chemical reaction in which there is an exchange of the α-amino group of one amino acid for the keto group of an α-keto acid, with the resulting synthesis of a second α-amino acid and a new α-keto acid. This type of chemical conversion was first described in 1937 and was postulated to be a reaction which occurred with any amino acid and α-ketoglutarate or oxalacetate, using pigeon breast muscle as a source of transaminase.9 In 1938, pig heart muscle was also shown to act as a transaminase.29 In 1940, it was

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