Factors determining the transplantability and rate of growth of tumors are many. Among these are the nature and degree of malignancy of the tumor tissue, responsiveness of the site of transplant to the new growth, the degree of trauma incident to the transplantation, and the nutritional status of the implanted area.Surgeons have long been familiar with the distressing frequency of recurrence of tumors in operative scars 1 and have taken steps to amend their techniques so as to avoid this unnecessary complication.2-4 When a tumor is inoperable or where removal is necessarily incomplete, the rate of regrowth following surgery has ofttimes been noted to be excessive, far outstripping the calculated growth rate prior to surgical intervention.5 In such instances, the trauma of surgery perhaps favors rapid proliferation of cancer cells by upsetting whatever balance between growth and growth resistance was previously operative.It has also been
FERGUSON LK, EDWARDS MH. Tumor Implantation at Paracentesis Sites. AMA Arch Intern Med. 1957;99(2):307–310. doi:10.1001/archinte.1957.00260020143022
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